Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities

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Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities

Identification of unintended drug effects, specifically drug repurposing opportunities and adverse drug events, maximizes the benefit of a drug and protects the health of patients. However, current observational research methods are subject to several biases. These include confounding by indication, reverse causality and missing data. We propose that Mendelian randomization (MR) offers a novel ...

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ژورنال

عنوان ژورنال: International Journal of Epidemiology

سال: 2017

ISSN: 0300-5771,1464-3685

DOI: 10.1093/ije/dyx207